Liposome-Encapsulated Photosensitizers Against Bacteria
Chin-Tin Chen, Chueh-Pin Chen, Jen-Chang Yang and Tsuimin Tsai
Affiliation: Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
Keywords: Antibiotic-resistant, bacteria, liposome, photodynamic inactivation, photodynamic therapy, photosensitizer.
Photodynamic therapy (PDT), utilizing photosensitizers and light, has received considerable interests for its potential
to treat microbial infections. The advantages of antimicrobial PDT include a broad spectrum of action, efficient
killing against wild-type as well as drug-resistant pathogens. Therefore, antimicrobial PDT could be valuable to rapidly
reduce the microbial burden during the management of local infections, especially for the antibiotic resistance. A variety
of photosensitizers have been examined its efficacy against pathogens. To increase the efficacy of photosensitizers, various
drug delivery systems have been developed. Among these carrier systems, liposomes showed their PDT efficacy and
safety in delivering photosensitizers. This review is focused on the application of liposomes mediated photodynamic inactivation
of bacteria along with the discussion of few of recent patents.
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