In this article we present an update on the applications of chemiluminescence coupled with flow injection
analysis for the determination of pharmaceuticals. Several reported applications of flow and sequential injection chemiluminescence
(FI-CL/SI-CL) in pharmaceuticals concern greatly on quality control, investigation of dissolution of particular
formulations or process control of production of pharmaceuticals and their presence in physiological fluids. A number of
advances in the development of FI-CL methods have been reported in recent years on pharmaceutical analysis.
In the present review we have covered six years period from Jan-2007 to Dec-2012 discussing FI-CL/SI-CL in the liquid
phase as an analytical tool for the determination of pharmaceuticals in diverse samples. We reviewed the methods as per
general CL reaction involved with the help of 321 cited references. Interesting features of the FI-CL methods like the use
of molecularly imprinting polymers for selectively and specially designed cells/microfluidic devices or lab-on-a-chip for
better detection or sensitivity were also presented.
Keywords: Flow injection analysis, sequential injection, chemiluminescence, pharmaceuticals, biomedical applications, microfluidics.
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