Cutaneous fibrosis seen in systemic sclerosis (SSc) is a generalized connective tissue disorder, characterized by
a wide spectrum of microvascular and immunological abnormalities. Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter
and immune modulator, is also an important mediator of bidirectional interactions between the vasoactive
amines and the skin.5-HT, a commonly secreted amine, is a known inducer of fibrosis, although the mechanistic basis for
it and growth factors regulating fibrosis and proliferation in the microenvironment are unclear. We review that as serotonin
has powerful vasodilator, immunomodulator, and growth factor actions, this pathway could be involved in skin
fibrotic. Since serotoninergic system play a role in skin fibrotic, and 5-HTs drugs, an usual treatment for this type of
patients. These provides a future perspective for research and drug development.