Functional Genome-wide Analysis: a Technical Review, Its Developments and Its Relevance to Cancer Research
James R Powell,
Simon H Reed.
A technique has emerged over the past decade combining chromatin immunoprecipitation with DNA microarray
analysis. This is a powerful and sensitive strategy that has been used extensively to characterise protein interactions
with chromatin and epigenetic changes such as acetylation and methylation throughout the genome of different organisms.
This technique has revolutionised our understanding of molecular genomics, continues to be widely used and is currently
being applied in novel areas of cancer research. In this publication we review the historical context of this technology and
offer current and future perspectives on how this technique is currently being developed and modified to allow its use in
novel areas of research. We discuss the potential for this technique and its ongoing important role in biological research
particularly in relation to cancer research. We also offer insight into the potential clinical application of this technology in
stratified medicine, particularly in the field of cancer therapy.
Keywords: DNA, DNA damage, microarrays, genome and cancer.
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