In recent decades, growth of computing power has facilitated powerful techniques for reconstructing evolutionary
relationships from online genetic and proteomic databases. These methods are useful tools for pharmacologists for
analyzing relationships between receptors and associated enzymes. Phylogenetic analysis can help generate hypotheses
and leads for experimentation. Reconstruction of molecular phylogenies for the nonspecialist is described in this article
using the example of the orphaned g protein coupled receptor GPR18.
Keywords: Amino acid sequence, drug discovery, evolutionary biology, molecular phylogenetics, nucleotide sequence.
Rights & PermissionsPrintExport