Biosensors are used for a variety of applications in medicine and biology. A critical step during the development of such devices
is the coordination of biological and technical requirements. The design of the device, as well as of the sample chamber and its
functionalized surface is of great importance. Depending on the surface, the method of coupling of the desired receptor has to be adapted
to guarantee functionality and biological activity during the measuring process. By using the SNAP-tag technology, a site-specific coupling
of molecules with unaltered activity to a variety of O6-benzylguanine functionalized surfaces is possible, making it a versatile tool
for the setup of biomedical devices.
Keywords: SNAP-tag, NCO-sP(EO-stat-PO), protein immobilization, biochip, surface functionalization, microfluidic.
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