The Role of SNAP-tag in Technical Approaches

Author(s): Christoph Stein, Christiane Puettmann, Daniel Haamann, Martin Moeller, Doris Klee.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 30 , 2013


Biosensors are used for a variety of applications in medicine and biology. A critical step during the development of such devices is the coordination of biological and technical requirements. The design of the device, as well as of the sample chamber and its functionalized surface is of great importance. Depending on the surface, the method of coupling of the desired receptor has to be adapted to guarantee functionality and biological activity during the measuring process. By using the SNAP-tag technology, a site-specific coupling of molecules with unaltered activity to a variety of O6-benzylguanine functionalized surfaces is possible, making it a versatile tool for the setup of biomedical devices.

Keywords: SNAP-tag, NCO-sP(EO-stat-PO), protein immobilization, biochip, surface functionalization, microfluidic.

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Article Details

Year: 2013
Page: [5449 - 5456]
Pages: 8
DOI: 10.2174/1381612811319300016
Price: $58

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PDF: 11