Nanosponge: A Novel Carrier for Drug Delivery
Rehana Ansari, Rachna Maheshwari, Shikha Jain, Suresh C. Mahajan and Vikas Jain
Affiliation: Mahakal Institute of Pharmaceutical Studies, Ujjain (M.P.), India.
Nanosponges are nanosized novel drug delivery systems which are developed by cross linking the polymers
with the cross linking agent. The most commonly used polymer is β-cyclodextrin because it is biodegradable and can form
nanosponge having crystalline or amorphous porous structure and spherical shape with uniformity. These nanosponges
have the ability to encapsulate lipophillic as well as hydrophilic moiety. The release rate of the drug can be modulated by
varying the ratio of polymer to cross linking agent. Nanosponges are very minute structures such that they can be used for
targeting the drug to the specific site by conjugating the ligands onto their surface. Nanosponges can be employed to enhance
the aqueous solubility of poorly water soluble drugs, improve bioavailability, and protect photo sensitive drugs, for
sustained release and for site specific drug delivery. Nanosponge technology is also employed in the fields other than
pharmacy and medicine like water purification, for pollution free environment, in gas storage and also in agriculture. It is
a unique and multifunctional technology, considered to be suitable for the drug delivery.
Keywords: β-cyclodextrin, bioavailability, cross-linking, nanosponge, sustained drug delivery.
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