A protocol describes the synthesis of naphtha-1,3-oxaizine derivatives via one-pot multi-component reaction of α-naphthol, formaldehyde and various substituted anilines catalyzed by L-proline as an efficient catalyst. A method offers
delightful advantages such as mild reaction conditions, environmentally benign, easy experimental workup and good to
Keywords: Naphthoxazine, α-Naphthol, Formaldehyde, Aniline, L-proline.
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