Long term tamoxifen citrate therapy is imperative to treat several dermatological and hormonal sensitive disorders.
Successful oral and parenteral administration of tamoxifen citrate has been challenging since it undergoes enzymatic
degradation and has poor aqueous solubility issues. In the present work, tamoxifen citrate loaded ethosomes were prepared
and characterized for transdermal applications. The prepared formulations were characterized for morphological
features, particle size distribution, calorimetric attributes, zeta potential and drug entrapment. Permeation profile of prepared
ethosomes was compared with liposomes and hydroethonalic solution across cellophane membrane and human cadaver
skin. Results of the permeation studies indicate that ethosomes were able to deliver >90% drug within 24 hours of
application, while liposomes and hydroethanolic solution delivered only 39.04% and 36.55% respectively. Skin deposition
and stability studies are also reported.
Keywords: Tamoxifen Citrate, Ethosomes, Liposomes, Transdermal, Skin.
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