New Issues for Copper-64: from Precursor to Innovative Pet Tracers in Clinical Oncology
Giuseppe Lucio Cascini.
The role of copper in the metabolism of human cancer cells has been largely investigated in the last 20 years
and a strong relationship between copper levels and cancer progression has been demonstrated. Moreover copper is involved
in tumor angiogenesis as well as in non-neoplastic conditions like neurodegenerative diseases. The main mechanism
of action is related to a cellular transporter (CTR1) that plays a pivotal role in preserving the intra-cellular homeostasis,
allowing at the same time the anti- tumor activity of platinum based therapies. Copper-64, emitting positrons and ß -
radiations, is suitable for the labeling of a large number of molecules that could be used for radionuclide imaging, being
also usable in radionuclide therapy. Nevertheless few data are at present available on radiotracers labeled with radiocopper
and in particular on the use of 64Cu-Cl2 in cancer patients. In this paper we analyze the potential applications for
Copper-64 as PET agent in the clinical oncological scenario.
Keywords: Copper-64, molecular imaging, chemo-resistance, breast cancer, prostate cancer.
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