Current Trends in Microsponge Drug Delivery System

Author(s): H.V. Gangadharappa, N. Vishal Gupta, Sarat Chandra Prasad M., H.G. Shivakumar.

Journal Name: Current Drug Delivery

Volume 10 , Issue 4 , 2013

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Abstract:

Microsponge is a microscopic sphere capable of absorbing skin secretions, therefore reducing the oiliness of the skin. Microsponge having particle size of 10-25 microns in diameter, have wide range of entrapment of various ingredients in a single microsponges system and release them at desired rates. Conventional topical preparations have various disadvantages due to irritancy, odour, greasiness and patient compliance. In many topical dosage forms fail to reach the systemic circulation in sufficient amounts in few cases. These problems overcome by the usage of formulation as microsponge in the areas of research. Drug release in microsponge is done by the external stimuli like pH, temperature and rubbing. It has several advantageous over the other topical preparations in being non-allergenic, non-toxic, non-irritant and non- mutagenic. These microsponges are used in the sun screens, creams, ointments, over-the-counter skin care preparations, recently nanosponge were reported in literature used in delivery of drug by the use of cyclodextrins to enhance the solubility of poorly water soluble drugs, which are meant for topical application.

Keywords: Microsponge, Nanosponge, Topical preparations.

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2013
Page: [453 - 465]
Pages: 13
DOI: 10.2174/1567201811310040010
Price: $58

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