The effects of permeation enhancers and sonophoresis on the transdermal permeation of lercanidipine hydrochloride
(LRDP) across mouse skin were investigated. Parameters including drug solubility, partition coefficient, drug
degradation and drug permeation in skin were determined. Tween-20, dimethyl formamide, propylene glycol, poly ethylene
glycol (5% v/v) and different concentration of ethanol were used for permeation enhancement. Low frequency ultrasound
was also applied in the presence and absence of permeation enhancers to assess its effect on augmenting the permeation
of drug. All the permeation enhancers, except propylene glycol, increased the transdermal permeation of LRDP.
Sonophoresis significantly increased the cumulative amount of LRDP permeating through the skin in comparison to passive
diffusion. A synergistic effect was noted when sonophoresis was applied in presence of permeation enhancers. The
results suggest that the formulation of LRDP with an appropriate penetration enhancer may be useful in the development
of a therapeutic system to deliver LRDP across the skin for a prolonged period (i.e., 24 h). The application of ultrasound
in association with permeation enhancers could further serve as non-oral and non-invasive drug delivery modality for the
immediate therapeutic effect.
Keywords: Lercanidipine hydrochloride, Transdermal, Ultrasound, Chemical enhancer, Skin delivery.
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