The aim of the present work was to develop and evaluate stomach-specific controlled release, gastroretentable
mucoadhesive patch of lercanidipine HCl. This drug is essentially soluble in gastric pH range of 1- 4 and have a partition
coefficient (log p-value) of 6.1; according to this concept, it has been decided to formulate the gastroretentive bioadhesive
patch. The patch system consisted of a drug release rate controlling film, using the combination of Eudragit RSPO and
RLPO; mucoadhesive film by using the combination of various hydrophilic polymers. Bilayered patch were made by using
the selected batch of two films using the layering method and evaluated for the various parameters like in vitro swelling
study, ex vivo mucoadhesive strength. Film was folded into a hard gelatin capsule, evaluated for in vitro drug release
in pH 1.2 containing 0.2% (w/v) sodium lauryl sulphate (SLS), and in vivo bioavailability in rabbits. Patches could control
the drug release up to 12 h, having mucoadhesion strength in the range of 4.05±0.4 N to 4.52±0.12 N. In vivo bioavailability
results indicate that the gastroretentive patch system provides a novel way to retain the drug matrix for the longer period
of time in a stomach, enhance drug absorption and thereby offer a promising strategy for gastroretentive mucoadhesive
drug delivery for the lercanidipine HCl.
Keywords: Bilayered patch, gastroretentable patch, lercanidipine HCl, mucoadhesive patch, stomach-specific controlled release.
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