5-Chloro-7-(2-phenylethynyl)quinolin-8-ol and 7-iodo-5-(2 -phenylethynyl)quinolin-8-ol was synthesized by
Pd-CuI catalyzed Sonogashira-type cross-coupling of 8-(benzyloxy)-5-chloro-7-iodoquinoline and 8-(benzyloxy)-5,7-
diiodoquinoline with 1-ethynylbenzene. The coupling products were smoothly debenzylated by boron trichloride in
dichloromethane to afford the corresponding products in good yields.
Keywords: Sonogashira, Coupling, Ethynylbenzene, Quinoline, Palladium.
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