Frontiers in Drug Discovery

Frontiers in Drug Discovery

Volume: 1

Erythropoietic Stimulating Agents

Indexed in: EBSCO.

The development of new erythropoietic stimulating agents (ESAs) has significantly increased in recent years. Researchers are focused on different and interesting concepts, namely, methods to increase ...
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Erythropoietin – A Possible Adjunctive Therapy for Cerebral Malaria

Pp. 232-254 (23)

Casper Hempel and Jørgen A.L. Kurtzhals

Abstract

Cerebral malaria a severe complication of an infection caused by the parasite Plasmodium falciparum. It is an acute encephalopathy and currently the adjunctive therapy supporting the anti-malarial treatment consists of glucose and oxygen supplementation. Wishing to improve the adjunctive therapy, we have studied the use of erythropoietin (EPO) and its possible neuroprotective effects in a murine model of cerebral malaria. EPO reduces the mortality and neuropathology in this model and is well tolerated. Our research is discussed in relation to the current literature and the potential as using EPO as adjunct therapy in humans is discussed.

Keywords:

Cerebral malaria, Plasmodium, murine models, erythropoietin, adjunctive therapy, inflammation, hypoxia, neuropathology, neuroregeneration.

Affiliation:

entre for Medical Parasitology, Department of Clinical Microbiology and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Denmark.