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Current Molecular Pharmacology
ISSN (Print): 1874-4672
ISSN (Online): 1874-4702
VOLUME: 6
ISSUE: 2
DOI: 10.2174/18744672113069990036      Price:  $58









Bile Salt Export Pump (BSEP/ABCB11): Trafficking and Sorting Disturbances

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Author(s): Hisamitsu Hayashi and Yuichi Sugiyama
Pages 95-103 (9)
Abstract:
Bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and mediates the efficient biliary excretion of bile acid. The secretion of bile acid into bile by BSEP provides the primary osmotic driving force for bile flow generation. Intrahepatic cholestasis resulting from dysfunction of BSEP can be caused by a mutation in the gene encoding this protein or by acquired factors, such as the side effects of xenobiotics and drugs. In some pathophysiological states, inhibition of BSEP function is associated with its reduced expression on the canalicular membrane caused by impaired trafficking and sorting of BSEP. This fact has generated interest in better understanding the trafficking and sorting mechanism of BSEP. This review describes the molecular characteristics and physiological roles of BSEP, the trafficking and sorting machinery of BSEP, and the mechanisms responsible for disturbance of BSEP, which causes intrahepatic cholestasis.
Keywords:
ATP-binding cassette (ABC) transporters, bile acid, bile formation, Bile Salt Export Pump (BSEP), cholestasis, protein trafficking, protein degradation.
Affiliation:
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.