Abstract
Amino acid transporters of the SLC6 family mediate the Na+-dependent uptake of neutral amino acids into neurons and epithelial cells of the intestine, kidney and other organs. They are integral parts of amino acid homeostasis in the whole body and the brain. In the intestine they are involved in protein absorption, while in the kidney they regulate plasma amino acid concentrations through reabsorption. The metabolic role of SLC6 amino acid transporters in the brain is less clear and most likely related to anaplerosis of the TCA cycle. Mutations in these transporters cause rare inherited disorders such as Hartnup disorder and iminoglycinuria. They may also play a role in complex traits such as depression, anxiety, obesity, diabetes and cancer. The review does not cover the transport of neurotransmitter amino acids.
Keywords: Cancer, diabetes, hartnup disorder, iminoglycinuria, obesity.
Current Molecular Pharmacology
Title:Diseases Associated with General Amino Acid Transporters of the Solute Carrier 6 Family (SLC6)
Volume: 6
Author(s): Stefan Broer
Affiliation:
Keywords: Cancer, diabetes, hartnup disorder, iminoglycinuria, obesity.
Abstract: Amino acid transporters of the SLC6 family mediate the Na+-dependent uptake of neutral amino acids into neurons and epithelial cells of the intestine, kidney and other organs. They are integral parts of amino acid homeostasis in the whole body and the brain. In the intestine they are involved in protein absorption, while in the kidney they regulate plasma amino acid concentrations through reabsorption. The metabolic role of SLC6 amino acid transporters in the brain is less clear and most likely related to anaplerosis of the TCA cycle. Mutations in these transporters cause rare inherited disorders such as Hartnup disorder and iminoglycinuria. They may also play a role in complex traits such as depression, anxiety, obesity, diabetes and cancer. The review does not cover the transport of neurotransmitter amino acids.
Export Options
About this article
Cite this article as:
Broer Stefan, Diseases Associated with General Amino Acid Transporters of the Solute Carrier 6 Family (SLC6), Current Molecular Pharmacology 2013; 6 (2) . https://dx.doi.org/10.2174/18744672113069990034
DOI https://dx.doi.org/10.2174/18744672113069990034 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mitochondrial Functionality and Chemical Compound Action on Sperm Function
Current Medicinal Chemistry Is Knowledge Enough? The Relationship Between Mental Health Knowledge and Stigmatising Attitudes Among Australian Adolescents
Adolescent Psychiatry Angelica Injection Promotes Peripheral Nerve Structure and Function Recovery with Increased Expressions of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Diabetic Rats
Current Neurovascular Research Carbon Monoxide in Acute Lung Injury
Current Pharmaceutical Biotechnology Targeting the JNK Pathway for Therapeutic Benefit in CNS Disease
Current Drug Targets - CNS & Neurological Disorders Radiopharmaceuticals Regulations: Current Scenario and the Way Forward
Applied Clinical Research, Clinical Trials and Regulatory Affairs Viruses in Semen and Male Genital Tissues - Consequences for the Reproductive System and Therapeutic Perspectives
Current Pharmaceutical Design Review: Involvement of the Cavum Septi Pellucidi and the Fornix in the Neuropathology of Schizophrenia and Affective Disorders
Current Psychiatry Reviews Commentary : Hypothesis Focused Ultrasound and NXY-059 in Experimental Cerebral Ischemia: A New Therapeutic Opportunity?
CNS & Neurological Disorders - Drug Targets Anticancer Vitamin K3 Analogs: A Review
Anti-Cancer Agents in Medicinal Chemistry Management of Acute Coronary Syndromes in Patients with Renal Insufficiency
Current Cardiology Reviews Protein Quality Control in Alzheimers Disease: A Fatal Saviour
Current Drug Targets - CNS & Neurological Disorders Control of Neuropathic Pain by Immune Cells and Opioids
CNS & Neurological Disorders - Drug Targets Migraine in Systemic Autoimmune Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Therapeutic and Mechanistic Effects of Curcumin in Huntington’s Disease
Current Neuropharmacology Protein Conformational Misfolding and Amyloid Formation: Characteristics of a New Class of Disorders that Include Alzheimers and Prion Diseases
Current Medicinal Chemistry DNMT3B Promoter Polymorphisms and Risk of Late Onset Alzheimer’s Disease
Current Alzheimer Research Henoch Schonlein Purpura in Childhood
Current Pediatric Reviews The Metabolomic Strategy in Tuberculosis Therapy
Combinatorial Chemistry & High Throughput Screening Desmopressin 30 Years in Clinical Use: A Safety Review
Current Drug Safety