This review examines the biological role of oxidants and antioxidants continuously produced by all living cells.
Physiologically, human beings, who have inherited good genes, used to eat moderately a healthy diet and exercised daily,
both systems are equally important and essential in maintaining a normal long life. However, the aging process slowly
leads to a disequilibrium that is accentuated in pathologies such as diabetes, cardiovascular, degenerative, pulmonary, infective
diseases, and cancer. All of these diseases shorten the life span in about 80% of individuals and represent a huge
social-economic problem for health authorities. Several factors such as excessive feeding, smoking, alcoholism, and a
poor life-style conjure up to their realization. Their progress, initially promoted by some pathogens and a wrong life-style,
is deeply accentuated by an excessive and deranged production of deadly oxidants no longer tameable by an inhibited control
of the antioxidant defences. Effective orthodox drugs are able to slow down these ailments but they impoverish the
quality of life because they cannot reactivate the innate ability to restore the complexity of the antioxidant system. Several
potential approaches to renew this system have been discussed and their possible roles to reactivate a valid protection in at
least some of the outlined pathologies. It is hoped to evaluate this integrated medical approach because it represents a
sheet anchor for many patients.
Keywords: Antioxidants, caloric restriction, chronic oxidative stress, exercise stress, ozonetherapy, reactive oxygen species,
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