Formulation of Fenofibrate Liquisolid Tablets Using Central Composite Design
Liquisolid technique has been widely used to enhance the dissolution of poorly water soluble drugs. The present
investigation is on formulation of liquisolid tablets of fenofibrate, a lipid lowering agent. Liquisolid formulation was
prepared by applying central composite design (CCD) to optimize various formulation parameters. Amounts of PEG 600
(X1), Avicel PH 102 (X2), and Aerosil 200 (X3) were selected as independent variables while the angle of repose, hardness,
disintegration time, and T90% (time required to release 90% drug) of liquisolid tablets were selected as dependent
variables. Optimization of formulation was done by multiple linear regression analysis. The results indicated amounts of
PEG 600 and Aviel PH 102 show greater effect on dependant variables. In vitro dissolution of fenofibrate in liquisolid
formulations was enhanced compared to the pure form. To conclude, Liquisolid technique is a promising strategy in improving
dissolution of poorly water soluble fenofibrate.
Keywords: Central Composite Design, Dissolution Enhancement, Fenofibrate, Liquisolid System.
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