Aspirin: A Potential Therapeutic Approach in Pancreatic Cancer

Author(s): Xin Shen, Liang Han, Zhenhua Ma, Chao Chen, Wanxing Duan, Shuo Yu, Pei Li, Lun Zhang, Wei Li, Qinhong Xu, Qingyong Ma.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 33 , 2013

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Abstract:

Inflammation has become a research hotspot in solid tumours and has been confirmed as a key factor in tumour development through the interactions of inflammatory mediators with gene expression, cell proliferation, and apoptosis. Pancreatic cancer (PC) is one of the most aggressive and deadliest forms of gastrointestinal cancer. A large case-control study found that aspirin, an anti-inflammatory drug, was associated with a decreased risk of PC. Moreover, aspirin has been shown to have inhibitory effects on PC in both in vitro and in vivo studies. However, the clinical data analysis has not been similarly promising. Results from genetic and pharmacological studies suggest that the anti-tumour effects of aspirin are mediated, at least in part, through the inhibition of COXs. Furtermore, other results suggest that the chemopreventive and therapeutic effects of aspirin are also mediated through COX-independent mechanisms. The COX-dependent and COX-independent mechanisms will be described in this review. In addition, we will discuss future research directions on the risks and benefits of the use of aspirin to treat PC and the potential cellular/molecular.

Keywords: Aspirin, anti-cancer therapy, chemopreventive effect, cellular target, COX2, inflammation, non-steroidal antiinflammatory drugs, pancreatic cancer.

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Article Details

VOLUME: 20
ISSUE: 33
Year: 2013
Page: [4153 - 4162]
Pages: 10
DOI: 10.2174/09298673113209990196
Price: $58

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