Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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The Mechanism of Calcitriol in Cancer Prevention and Treatment

Author(s): Jiguang Ma, Zhenhua Ma, Wei Li, Qingyong Ma, Jian Guo, Ang Hu, Rong Li, Fengfei Wang and Suxia Han

Affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, 277 West Yanta Road, Xi’an 710061, Shaanxi, China.

Keywords: Anti-proliferative, apoptosis, calcitriol, cancer prevention, chemotherapeutic agents, clinical trial, differentiation, retinoblastoma, signaling pathways, VDR.

Abstract:

Calcitriol (1, 25-dihydroxyvitamin D3) is the most biologically active metabolite derived from the secosteroid hormone vitamin D. Apart from its calcium homeostatic effects, epidemiological studies have shown that reduced serum calcitriol levels are associated with an increased risk of some types of cancer. Numerous recent epidemiological and experimental studies have reported that it elicits anti-proliferative, apoptotic and differentiation effects in several malignant cell types. The inhibition of calcitriol results in reduced effects of anticancer drugs. Results from a number of clinical trials revealed that sufficient dosing and exposure to calcitriol is critical for achieving antitumor effects during intermittent regimens. This review summarizes the role of calcitriol in anticancer therapy and the progress in understanding its mechanism.

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Article Details

VOLUME: 20
ISSUE: 33
Page: [4121 - 4130]
Pages: 10
DOI: 10.2174/09298673113209990195