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Current Medicinal Chemistry
ISSN (Print): 0929-8673
ISSN (Online): 1875-533X
VOLUME: 20
ISSUE: 33
DOI: 10.2174/09298673113209990195      Price:  $58









The Mechanism of Calcitriol in Cancer Prevention and Treatment

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Author(s): Jiguang Ma, Zhenhua Ma, Wei Li, Qingyong Ma, Jian Guo, Ang Hu, Rong Li, Fengfei Wang and Suxia Han
Pages 4121-4130 (10)
Abstract:
Calcitriol (1, 25-dihydroxyvitamin D3) is the most biologically active metabolite derived from the secosteroid hormone vitamin D. Apart from its calcium homeostatic effects, epidemiological studies have shown that reduced serum calcitriol levels are associated with an increased risk of some types of cancer. Numerous recent epidemiological and experimental studies have reported that it elicits anti-proliferative, apoptotic and differentiation effects in several malignant cell types. The inhibition of calcitriol results in reduced effects of anticancer drugs. Results from a number of clinical trials revealed that sufficient dosing and exposure to calcitriol is critical for achieving antitumor effects during intermittent regimens. This review summarizes the role of calcitriol in anticancer therapy and the progress in understanding its mechanism.
Keywords:
Anti-proliferative, apoptosis, calcitriol, cancer prevention, chemotherapeutic agents, clinical trial, differentiation, retinoblastoma, signaling pathways, VDR.
Affiliation:
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, 277 West Yanta Road, Xi’an 710061, Shaanxi, China.