Vitamin D - Pivotal Nutraceutical in the Regulation of Cancer Metastasis and Angiogenesis

Author(s): Jun Xu, Wei Li, Jiguang Ma, Jiangbo Liu, Huanchen Sha, Shuang Zhou, Fengfei Wang, Qingyong Ma.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 33 , 2013

Abstract:

Various epidemiological studies have demonstrated that vitamin D may play important roles in the pathogenesis and progression of cancer. Vitamin D is one of the most pivotal nutraceuticals whose active metabolite, calcitriol (1,25-dihydroxyvitamin D3), possesses anti-proliferative, pro-apoptotic, and pro-differentiating capabilities. Accumulating evidence indicates that the potential benefits of using vitamin D in cancer are not only anti-cancer cell proliferation which is linked with its anti-inflammatory effects, including the suppression of prostaglandin metabolism and inhibition of NF- B signaling, but also suppressing tumor metastasis and angiogenesis. Here, we present a systematic summary of the effects of vitamin D in the chemoprevention and chemotherapy of cancer, especially anti-metastatic and anti-angiogenic actions.

Keywords: Angiogenesis, calcitriol, cancer prevention, epidemiology, epithelial-mesenchymal transition, metabolism, metastasis, synthesis, vitamin D, review.

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Article Details

VOLUME: 20
ISSUE: 33
Year: 2013
Page: [4109 - 4120]
Pages: 12
DOI: 10.2174/09298673113209990194
Price: $58

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