Various epidemiological studies have demonstrated that vitamin D may play important roles in the pathogenesis
and progression of cancer. Vitamin D is one of the most pivotal nutraceuticals whose active metabolite, calcitriol
(1,25-dihydroxyvitamin D3), possesses anti-proliferative, pro-apoptotic, and pro-differentiating capabilities. Accumulating
evidence indicates that the potential benefits of using vitamin D in cancer are not only anti-cancer cell proliferation which
is linked with its anti-inflammatory effects, including the suppression of prostaglandin metabolism and inhibition of NF-
B signaling, but also suppressing tumor metastasis and angiogenesis. Here, we present a systematic summary of the effects
of vitamin D in the chemoprevention and chemotherapy of cancer, especially anti-metastatic and anti-angiogenic actions.
Keywords: Angiogenesis, calcitriol, cancer prevention, epidemiology, epithelial-mesenchymal transition, metabolism, metastasis,
synthesis, vitamin D, review.
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