The Proteasome as a Therapeutic Target for Lung Fibrosis
Leonard H.T. Go, Jinal K. Gangar and Manu Jain
Affiliation: Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, 240 E. Huron Ave., McGaw Mezzanine, Chicago, IL 60611, USA.
When extensive, fibrosis can impair the function of an affected organ. Despite a greater understanding of the
causes and processes leading to organ fibrosis, there are a limited number of treatment options with minimal data supporting
their utility. Identifying compounds for clinical use that inhibit fibrosis is an active area of investigation. In recent
years, evidence for the utility of targeting the ubiquitin-proteasome system (UPS) in the inhibition of fibrosis has grown.
Here we review the evidence for the interaction of the UPS with processes driving organ fibrosis, including the transforming
growth factor beta pathway. We will also discuss the potential utility and harm of proteasome inhibition in the treatment
of organ fibrosis.
Keywords: Bortezomib, fibrosis, proteasome, transforming growth factor-beta, ubiquitin
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