Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

Back

Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity

Author(s): Jingwei Zhang, Xusheng Shao, Zhong Li and Xiaoyong Xu

Affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Xiaoyong Xu.

Keywords: Divalent, Neonicotinoid, Activity, Insecticide.

Abstract:

Divalent ligand provides a special approach for designing bioactive molecules. Aiming at searching for novel insecticidal divalent neonicotinoid insecticides, bis-phenylazoneonicotinoids were designed and synthesized here using nitromethylene analogue of imidacloprid, diazo unit and benzene system as pharmacophore, linker and spacer, respectively. The designed divalent compounds exhibited moderate insecticidal activity against cowpea aphids (Aphis craccivora).

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 11
ISSUE: 2
Page: [150 - 155]
Pages: 6
DOI: 10.2174/15701808113109990049