Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity

Author(s): Jingwei Zhang, Xusheng Shao, Zhong Li, Xiaoyong Xu.

Abstract:

Divalent ligand provides a special approach for designing bioactive molecules. Aiming at searching for novel insecticidal divalent neonicotinoid insecticides, bis-phenylazoneonicotinoids were designed and synthesized here using nitromethylene analogue of imidacloprid, diazo unit and benzene system as pharmacophore, linker and spacer, respectively. The designed divalent compounds exhibited moderate insecticidal activity against cowpea aphids (Aphis craccivora).

Keywords: Divalent, Neonicotinoid, Activity, Insecticide.

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2014
Page: [150 - 155]
Pages: 6
DOI: 10.2174/15701808113109990049
Price: $58