Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity
Jingwei Zhang, Xusheng Shao, Zhong Li and Xiaoyong Xu
Affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Xiaoyong Xu.
Keywords: Divalent, Neonicotinoid, Activity, Insecticide.
Divalent ligand provides a special approach for designing bioactive molecules. Aiming at searching for novel
insecticidal divalent neonicotinoid insecticides, bis-phenylazoneonicotinoids were designed and synthesized here using nitromethylene
analogue of imidacloprid, diazo unit and benzene system as pharmacophore, linker and spacer, respectively.
The designed divalent compounds exhibited moderate insecticidal activity against cowpea aphids (Aphis craccivora).
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