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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
Epub Abstract Ahead of Print
DOI: 10.2174/15701808113109990047      Price:  $95









SYNTHESIS, BIOCHEMICAL EVALUATION AND RATIONALISATION OF A RANGE OF NOVEL THIOSEMICARBAZONE-BASED COMPOUNDS AS POTENTIALLY NEW CLASS OF DUAL INHIBITORS OF ESTRONE SULFATASE (ES) AND THE CYTOCHROME P-450 ENZYME AROMATASE (AR)

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Author(s): Balkrishna Bhamare, Sukriti Singh, Bhanu C. Rudra, Amit Kumar and Sabbir Ahmed
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Abstract:
A series of thiosemicarbazone-based compounds as potential dual inhibitors of ES and AR are reported. Results show the compounds to be weak inhibitors of both ezymes in comparison to the two standard inhibitors and are therefore good lead compounds in the search for thiosemicarbazone-based dual inhibitors of ES and AR.
Affiliation:
Institute of Biomedical and Environmental Health Research (IBEHR) School of Science Faculty of Science and Technology University of the West of Scotland High Street, Paisley PA1 2BE Scotland UK.