The Solubility and Stability of Amino Acids in Biocompatible Ionic Liquids

Author(s): T. Vasantha, Awanish Kumar, Pankaj Attri, Pannuru Venkatesu, R.S. Rama Devi.

Journal Name: Protein & Peptide Letters

Volume 21 , Issue 1 , 2014

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Abstract:

In recent years, ionic liquids (ILs) represent a new class of biocompatible co-solvents for biomolecules. In this work, we report the apparent transfer free energies (ΔG'tr) for six amino acids (AA) from water to aqueous solutions of six ammonium based ILs (diethylammonium acetate (DEAA), diethylammonium sulfate (DEAS), triethyl ammonium acetate (TEAA), triethylammonium sulfate (TEAS), triethylammonium dihydrogen phosphate (TEAP), and trimethylammonium acetate (TMAA)) through solubility measurements, as a function of IL concentration at 298.15 K under atmospheric pressure. Salting-out effect was found for AA in aqueous IL solutions with increasing IL concentrations. In addition, we observed positive values of ΔG'tr for AA from water to ILs, indicating that the interactions between ILs and AA are unfavorable. From the obtained results, we found that the selected ammonium based ILs act as stabilizers for the structure of AA.

Keywords: Amino acid, apparent transfer free energy, biomolecular interactions, ionic liquid, solubility.

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Article Details

VOLUME: 21
ISSUE: 1
Year: 2014
Page: [15 - 24]
Pages: 10
DOI: 10.2174/09298665113209990071

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