Abstract
This review article summarizes the recent information regarding general aspects in the automated synthesis of 18F-labelled PET radiotracers that are prepared via nucleophilic fluorination pathway. The previous and on-going researches in development of different automation solutions are discussed and the current trends in large scale production of radiotracers are considered. The advantages and limitations of the fully automated systems available from different manufacturers are exemplified by routine automated production of several clinically relevant 18F-radiotracers using traditional automated synthesizers, kit-based (cassette-type) radiochemistry modules and modular systems.
Keywords: Automation, F-18, Nucleophilic fluorination, PET radiopharmaceuticals, Synthesis modules.
Current Organic Chemistry
Title:PET Radiochemistry Automation: State of the Art and Future Trends in 18F-nucleophilic Fluorination
Volume: 17 Issue: 19
Author(s): Raisa Krasikova
Affiliation:
Keywords: Automation, F-18, Nucleophilic fluorination, PET radiopharmaceuticals, Synthesis modules.
Abstract: This review article summarizes the recent information regarding general aspects in the automated synthesis of 18F-labelled PET radiotracers that are prepared via nucleophilic fluorination pathway. The previous and on-going researches in development of different automation solutions are discussed and the current trends in large scale production of radiotracers are considered. The advantages and limitations of the fully automated systems available from different manufacturers are exemplified by routine automated production of several clinically relevant 18F-radiotracers using traditional automated synthesizers, kit-based (cassette-type) radiochemistry modules and modular systems.
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Cite this article as:
Krasikova Raisa, PET Radiochemistry Automation: State of the Art and Future Trends in 18F-nucleophilic Fluorination, Current Organic Chemistry 2013; 17 (19) . https://dx.doi.org/10.2174/13852728113179990102
DOI https://dx.doi.org/10.2174/13852728113179990102 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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