Driven Hematopoietic Differentiation of Embryonic Stem Cells: Epigenetic Perspectives

Author(s): Lenka Tesarova, Stanislav Stejskal, Irena Koutna.

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 11 , 2014

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Abstract:

Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cellreplacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.

Keywords: Epigenetic, stem cells, pluripotency, cell differentiation, hematopoietic development.

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Article Details

VOLUME: 20
ISSUE: 11
Year: 2014
Page: [1674 - 1686]
Pages: 13
DOI: 10.2174/13816128113199990524
Price: $58

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