The metabolic syndrome is a constellation of risk factors for cardiovascular diseases including: abdominal
obesity, a decreased ability to metabolize glucose (increased blood glucose levels and/or presence of insulin resistance),
dyslipidemia, and hypertension. Patients who have developed this syndrome have been shown to be at an increased risk of
developing cardiovascular disease and/or type 2 diabetes. Genetic factors and the environment both are important in the
development of the metabolic syndrome, influencing all single components of this syndrome.
The goals of therapy are to treat the underlying cause of the syndrome, to reduce morbidity, and to prevent complications,
including premature death. Lifestyle modification is the preferred first-step treatment of the metabolic syndrome. There is
no single effective drug treatment affecting all components of the syndrome equally known yet. However, each
component of metabolic syndrome has independent goals to be achieved, so miscellaneous types of drugs are used in the
treatment of this syndrome, including weight losing drugs, antidiabetics, antihypertensives, antilipemic and anticlothing
This article provides a brief insight into contemporary drug treatment of components the metabolic syndrome.