In the present review article we address the issue of the potential effect of renal sympathetic denervation (RSD)
on metabolic states associated with resistant hypertension. So far, there is an established pathophysiological background
denoting that abnormalities in glucose metabolism especially in obese patients and in those with sleep apnea are
constantly accompanied by increased sympathetic firing, as assessed by markers of sympathetic activity. Since resistant
hypertension is also characterized by enhanced sympathetic activity, it seems logical and biologically plausible, that RSD
might favorably influence impaired glucose metabolism, sleep disorders and increased body adiposity beyond BP
lowering. Despite the limited evidence from clinical trials, there are promising data suggesting that RSD indeed
ameliorates glucose metabolism-related measures in resistant hypertension. Well-designed randomized trials recruiting a
larger number of patients with hypertension, and focused on metabolic parameters, may refine the role of RSD as a
potential intervention to treat dysmetabolic states associated with hypertension.
Keywords: Insulin resistance, metabolism, polycystic ovary syndrome, renal sympathetic denervation, sleep apnea, weight loss.
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