Advanced Glycation End Products and Diabetic Retinopathy

Author(s): M. Chen, T.M. Curtis, A.W. Stitt.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 26 , 2013


Diabetic retinopathy (DR) has a complex pathogenesis which is impacted by a raft of systemic abnormalities and tissue-specific alterations occurring in response to the diabetes milieu. Many pathogenic processes play key roles in retinal damage in diabetic patients. One such pathway is the formation and accumulation of advanced glycation endproducts (AGEs) and advanced lipoxidation end products (ALEs) which are relevant modifications with roles in the initiation and progression of pathology. In this review, AGE/ALE formation in the diabetic retina is discussed alongside their impact on retinal cell function. In addition, various inhibitors of the AGE-RAGE system and their therapeutic utility for DR will also be evaluated.

Keywords: Diabetic retinopathy, advanced glycation end product, advanced lipoxidation end product, receptor for advanced glycation endproduct, inflammation, oxidative stress, inhibitor, fusion protein.

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Article Details

Year: 2013
Page: [3234 - 3240]
Pages: 7
DOI: 10.2174/09298673113209990025
Price: $58

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PDF: 27