Catalyst- and Solvent-free Three-component Synthesis of Phosphane Sulfides
Francisco Alonso and Yanina Moglie
Affiliation: Departamento de Quimica Organica, Facultad de Ciencias, and Instituto de Sintesis Organica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante Spain.
The first three-component synthesis of phosphane sulfides from diphenylphosphane, elemental sulfur, and α,β-unsaturated carbonyl compounds is presented. Reactions proceed under solvent-free conditions in the absence of catalyst,
providing the expected β-diphenylphosphorothioyl-functionalised products in moderate-to-high yields. Different experiments
revealed that the process takes place through the in situ formation of diphenylphosphane sulfide and subsequent
1,4-addition to the substrate.
Keywords: Alkenes, catalyst-free reactions, conjugate addition, green chemistry, hydrothiophosphorylation, multicomponent
reactions, phosphane sulfides, phosphines, solvent-free reactions, sulfides, α, β-unsaturated carbonyl compounds.
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