Abstract
In this study, multiwall carbon nanotubes (MWNTs) were modified and functionalized with Amantadine, Pregabalin and Alendronate. We investigated the formation of three anti cancer agents, functionalization on MWNTs, in addition to developing the amidation of MWNTs with amines. Functionalized carbon nanotubes were characterized by Fourier transform infrared (FT-IR), Raman, transmission electron microscopy (TEM), Ultra Violent spectroscopy (UV) and toxicity assay. Biological activity with human gastric cancer cells and MTT test for measurement of viable cell numbers were also performed.
Keywords: Functionalization, carboxylated multiwall carbon nanotubes, amantadine, pregabalin and alendronate.
Current Nanoscience
Title:Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives
Volume: 9 Issue: 4
Author(s): Javad Azizian, Ehsan Ardestani and Mahdieh Entezari
Affiliation:
Keywords: Functionalization, carboxylated multiwall carbon nanotubes, amantadine, pregabalin and alendronate.
Abstract: In this study, multiwall carbon nanotubes (MWNTs) were modified and functionalized with Amantadine, Pregabalin and Alendronate. We investigated the formation of three anti cancer agents, functionalization on MWNTs, in addition to developing the amidation of MWNTs with amines. Functionalized carbon nanotubes were characterized by Fourier transform infrared (FT-IR), Raman, transmission electron microscopy (TEM), Ultra Violent spectroscopy (UV) and toxicity assay. Biological activity with human gastric cancer cells and MTT test for measurement of viable cell numbers were also performed.
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Azizian Javad, Ardestani Ehsan and Entezari Mahdieh, Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives, Current Nanoscience 2013; 9 (4) . https://dx.doi.org/10.2174/1573413711309040004
DOI https://dx.doi.org/10.2174/1573413711309040004 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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