Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives
In this study, multiwall carbon nanotubes (MWNTs) were modified and functionalized with Amantadine, Pregabalin and Alendronate.
We investigated the formation of three anti cancer agents, functionalization on MWNTs, in addition to developing the amidation
of MWNTs with amines. Functionalized carbon nanotubes were characterized by Fourier transform infrared (FT-IR), Raman, transmission
electron microscopy (TEM), Ultra Violent spectroscopy (UV) and toxicity assay. Biological activity with human gastric cancer
cells and MTT test for measurement of viable cell numbers were also performed.
Keywords: Functionalization, carboxylated multiwall carbon nanotubes, amantadine, pregabalin and alendronate.
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