Chemotherapy has been performed to treat metastatic cancers but with varying degrees of success. The optimal potential of
chemotherapy has not been achieved yet. Numerous compounds cannot be further developed to produce potent drugs because these
compounds exhibit poor druggability. To resolve this issue, researchers developed prodrugs in drug discovery because these drugs can be
efficiently used. Many small-molecule prodrugs have been designed and synthesized as anticancer agents for several years, and great
progress has been achieved. In this study, recently developed, efficient anticancer prodrugs were reviewed, particularly small molecule
prodrugs. Moreover, small molecule anticancer prodrugs were summarized according to different types of chemical structures and properties.
Keywords: Anticancer, cancer, prodrug, small molecule, therapy.
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