Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides

Author(s): Katerina Tmejova, Ludmila Krejcova, David Hynek, Vojtech Adam, Petr Babula, Libuse Trnkova, Marie Stiborova, Tomas Eckschlager, Rene Kizek.

Abstract:

Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too.

Keywords: Adsorptive transfer stripping technique, DNA, differential pulse voltammetry, ellipticine, hetero-nucleotides, intercalation, square wave voltammetry, cancer, therapy.

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Article Details

VOLUME: 14
ISSUE: 2
Year: 2014
Page: [331 - 340]
Pages: 10
DOI: 10.2174/18715206113139990316
Price: $58