Design, Characterization and Pre-Clinical Evaluation of Aceclofenac Loaded Algino-gelatin Microspheres for Targeted Drug Delivery

Santanu      Chakraborty; Madhusmruti      Khandai; Ashoke   Kumar   Ghosh

Abstract

Multiple-unit type oral modified drug delivery system of aceclofenac was developed by ionotropic gelation method for targeted drug delivery and to reduce the chances of side effects. Various batches of microspheres were developed by ionotropic gelation method using single and blends of polymers. Along with usual physical properties, the microspheres were also subjected to enteric nature, in-vitro drug release and mucoadhesion studies to investigate a possible sustained drug release and their use in in-vivo as a gastro-protective system for aceclofenac. It was observed that prepared microspheres could be able to restrict the drug release in stomach region and prolong the drug release by adhering on to the intestinal mucosa. In vitro drug release suggested a combination of drug diffusion and spheres erosion could be the release mechanism and it was also found that blend of polymers is more effective in sustaining the drug release than either polymer. Optimized microsphere formulation suggested 71.03 ± 4.94 % edema inhibition at 12 hours and shelf life of about 2.32 years at room temperature. Algino-gelatin multiunit dosage system exhibits promising properties for once daily targeted release form of aceclofenac in order to reduce the side effects and enhance the patient’s compliance.

Keywords: Algino-gelatin microspheres, enteric nature, gastro-protection, in-vivo study, mucoadhesion, targeted release.

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