Green and Facile Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via a Click Reaction of α-Bromo Ketones, [bmim]N3 and Terminal Acetylenes

Author(s): Azadeh Fazeli, Hossein A. Oskooie, Yahya S. Beheshtiha, Majid M. Heravi, Hassan Valizadeh.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 10 , 2013

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Abstract:

An efficient and green one pot method is reported for regioselective synthesis of 1,4-disubstituted 1,2,3- triazoles. In this method, β-ketoazides are generated via in situ reaction between α-bromo ketones and 1-butyl-3- methylimidazolium azide [bmim]N3 in aqueous ethanol and reacted with terminal acetylenes using Cu-CuSO4 at room temperature to afford 1,4-disubstituted 1,2,3-triazoles.

Keywords: α-Bromo ketones, 1-butyl-3-methylimidazolium azide, click reaction, copper-copper sulfate, cycloaddition, 1, 4- disubstituted 1, 2, 3-triazoles, three component reaction.

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Article Details

VOLUME: 10
ISSUE: 10
Year: 2013
Page: [738 - 743]
Pages: 6
DOI: 10.2174/15701786113109990036
Price: $65

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