Copper and Iron-assisted Palladium-catalyzed Direct Arylation of Azoles with Arylboronic Acids under Ligand and Base-free Conditions

Author(s): Xiang-Mei Wu, Qiu-Xian Shen.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 9 , 2013

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Abstract:

The direct arylation of azoles with arylboronic acids is effectively promoted by PdCl2 in the presence of copper and iron salts under ligand and base-free conditions. This reaction can be applied to heterocycles such as benzothiazole, benzoxazole, 1-methylbenzimidazole and 4,5-dimethylthiazole with moderate to good yields.

Keywords: Palladium, copper, iron, arylation, arylboronic acid.

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Article Details

VOLUME: 10
ISSUE: 9
Year: 2013
Page: [668 - 673]
Pages: 6
DOI: 10.2174/15701786113109990034

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