Boron trifluoride supported on hydroxyapatite nanorods efficiently catalyzed the ring opening reaction of α-
epoxyketones in methanol solution to afford the corresponding α-hydroxy-β-methoxyketones through Cβ–O bond cleavage
in excellent yields at room temperature. The type and position of the additional substituent affect not only the rate of
ring opening but also the diastereomeric ratios products.
Keywords: Boron trifluoride, epoxyketones, hydroxyapatite, reusable, ring opening.
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