Gut-liver Axis and Microbiota in NAFLD: Insight Pathophysiology for Novel Therapeutic Target

Author(s): Luca Miele , Giuseppe Marrone , Cristiano Lauritano , Consuelo Cefalo , Antonio Gasbarrini , Chris Day , Antonio Grieco .

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 29 , 2013

Abstract:

There is increasing evidence for a correlation between intestinal microbiota, bacterial translocation and hepatic steatosis. Intestinal microbiota affects nutrient absorption and energy homeostasis. Altered intestinal permeability may favor the passage of bacteriaderived compounds into systemic circulation, causing a systemic inflammatory state, characteristic of the metabolic syndrome. The interaction between intestinal permeability and luminal bacteria is involved in the pathogenesis and evolution of non-alcoholic liver disease. Microbiota pharmacological modulation could be a promising tool for a new therapeutical approach to non-alcoholic fatty liver disease.

Keywords: Gut-liver axis, intestinal permeability, insulin resistance, human microbiota, NAFLD, portal hypertension.

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Article Details

VOLUME: 19
ISSUE: 29
Year: 2013
Page: [5314 - 5324]
Pages: 11
DOI: 10.2174/1381612811319290011
Price: $58

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