Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

Author(s): Xin Tong, Jill C. Pelling.

Abstract:

Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin’s inhibition of the PI3K/Akt/mTOR signaling pathways.

Keywords: Akt, mTOR, apigenin, cancer.

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Article Details

VOLUME: 13
ISSUE: 7
Year: 2013
Page: [971 - 978]
Pages: 8
DOI: 10.2174/18715206113139990119
Price: $58