Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention
Jill C. Pelling.
Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is
associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary
constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy
vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review
summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and
properties, with focus on mechanism related to apigenin’s inhibition of the PI3K/Akt/mTOR signaling pathways.
Keywords: Akt, mTOR, apigenin, cancer.
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