Binding Modes of Chain Arylpiperazines to 5-HT1a, 5-HT2a and 5-HT7 Receptors

Author(s): Anna Bielenica, Anna E. Koziol, Marta Struga.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 10 , 2013

Become EABM
Become Reviewer


An overview of docking models of chain arylpiperazines to different subtypes of serotonin receptors belonging to the GPCR family is presented. The theory of a ligand-receptor interaction has been briefly summarized. The review covers more than twenty models, beginning with the early models of a ligand interaction with the 5-HT1A and 5-HT2A receptor, and ending with a ligand-5-HT7 receptor docking studies.

Keywords: Docking, arylpiperazines, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptor.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Page: [1516 - 1539]
Pages: 24
DOI: 10.2174/1389557511313100012
Price: $58

Article Metrics

PDF: 11