In the present research, anti-inflammatory and analgesic activities of the synthesized agents derived from Ugi
four-component reaction (Ugi-4CR) have been described. The synthesis was initiated by the imine formation under
microwave irradiation. Ugi-4CR adducts has been achieved by the condensation of imine with aromatic aldehyde, 4-
aminoantipyrine and ethylisocyanoacetate. The reaction was carried out at room temperature in presence of Fluorite as a
catalyst. The novel Ugi derivatives were characterized on the basis of IR, 1H NMR, 13C NMR, Mass and Elemental
analysis. All the synthesized agents were screened for their potential anti-inflammatory and analgesic activities using
healthy wistar albino rats. Anti-inflammatory and analgesic activities were evaluated by Mercury displacement and Hot
plate method using Diclofenac and Morphine Sulfate as standard reference drugs respectively. The screening data shows
that synthesized compounds are potent agents to act as analgesic and anti-inflammatory drugs.
Keywords: Analgesic, Anti-inflammatory, Fluorite, Green synthesis, Microwave irradiation, Ugi-4CR.
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