Nanotechnological Strategies to Improve Antifungal Therapy
A. C. Amaral and M. S.S. Felipe
Affiliation: Biological Sciences Institute, University of Brasilia, Asa Norte, Brasilia, Distrito Federal, CEP 70910- 900, Brazi.
Because of the increasing number of cases of mycosis that are resistant to treatment and the incidence of fungal
infections, there is an urgent need to develop new and efficient drugs for antifungal therapies. Because the development of
new drugs is expensive and time consuming, one strategy is the use of nanotechnology for drug delivery systems to
prolong the use of the currently available antifungal agents. Several efforts are being expended to achieve these goals. In
this review, some examples of patents filed that claim the development of nanostructured drugs, primarily through the use
of liposomes, polymeric nanoparticles and nanomaterials that possess antimicrobial activity, are presented. In addition to
the presented examples, there are many possibilities to be explored in this field for developing new treatment choices to
prevent and even to cure important global diseases, such as mycosis.
Keywords: Nanotechnology, nanoparticles, antifungal agents, amphotericin, mycosis.
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