Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones

Author(s): Zafer Asım Kaplancıklı, Leyla Yurttas, Gülhan Turan-Zitouni, Ahmet Özdemir, Gamze Göger, Fatih Demirci, Usama Abu Mohsen.


The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide was refluxed with different aromatic aldehydes/ketones in ethanol to yield N’-(arylidene)-2-[(pyrimidine-5-yl)thio]- acetohydrazide derivatives (3a-l). The structures of the compounds were elucidated by NMR, FTIR, MS, and elemental analyses. Additionally the final compounds (3a-l) were evaluated for their antimicrobial activity using a microdilution method against a panel of pathogenic Gram positive, Gram negative, and fungus strains, i.e. Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Bacillus subtilis, Serrratia marcescens, Staphylococcus epidermidis, and Candida utilis. Compound N’-(2-pyrilidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide (3a) possessing a 2- pyridyl moiety was found to be the most active (MIC= 31.25-250 g/mL) derivative toward the tested microorganisms.

Keywords: Pyrimidine, Hydrazone, Antimicrobial activity.

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Article Details

Year: 2014
Page: [76 - 81]
Pages: 6
DOI: 10.2174/15701808113109990037