Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones

Author(s): Zafer Asım Kaplancıklı, Leyla Yurttas, Gülhan Turan-Zitouni, Ahmet Özdemir, Gamze Göger, Fatih Demirci, Usama Abu Mohsen.

Abstract:

The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide was refluxed with different aromatic aldehydes/ketones in ethanol to yield N’-(arylidene)-2-[(pyrimidine-5-yl)thio]- acetohydrazide derivatives (3a-l). The structures of the compounds were elucidated by NMR, FTIR, MS, and elemental analyses. Additionally the final compounds (3a-l) were evaluated for their antimicrobial activity using a microdilution method against a panel of pathogenic Gram positive, Gram negative, and fungus strains, i.e. Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Bacillus subtilis, Serrratia marcescens, Staphylococcus epidermidis, and Candida utilis. Compound N’-(2-pyrilidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide (3a) possessing a 2- pyridyl moiety was found to be the most active (MIC= 31.25-250 g/mL) derivative toward the tested microorganisms.

Keywords: Pyrimidine, Hydrazone, Antimicrobial activity.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2014
Page: [76 - 81]
Pages: 6
DOI: 10.2174/15701808113109990037