Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones
Zafer Asım Kaplancıklı,
Usama Abu Mohsen.
The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial
activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide was refluxed
with different aromatic aldehydes/ketones in ethanol to yield N’-(arylidene)-2-[(pyrimidine-5-yl)thio]-
acetohydrazide derivatives (3a-l). The structures of the compounds were elucidated by NMR, FTIR, MS, and elemental
analyses. Additionally the final compounds (3a-l) were evaluated for their antimicrobial activity using a microdilution
method against a panel of pathogenic Gram positive, Gram negative, and fungus strains, i.e. Escherichia coli, Pseudomonas
aeruginosa, Salmonella typhimurium, Bacillus cereus, Bacillus subtilis, Serrratia marcescens, Staphylococcus epidermidis,
and Candida utilis. Compound N’-(2-pyrilidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide (3a) possessing a 2-
pyridyl moiety was found to be the most active (MIC= 31.25-250 g/mL) derivative toward the tested microorganisms.
Keywords: Pyrimidine, Hydrazone, Antimicrobial activity.
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