Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Antifungal Activity of a Library of Cyclitols and Related Compounds

Author(s): Ana Bellomo, Ana Bertucci, Victoria de la Sovera, Gonzalo Carrau, Marcela Raimondi, Susana Zacchino, Helio A. Stefani, David Gonzalez.


The antifungal activity of a library of 32 cyclitols and derivatives, including 6 previously unreported cyclitol amino acid conjugates, was studied against the clinically important yeasts Candida albicans, Candida tropicalis and Cryptococcus neoformans along with Saccharomyces cerevisiae. Bioautography followed by standardized microbroth dilution methods were used and allowed to identify an azidoinositol glycoside (11) and an azidoconduritol linked to an aromatic aldehyde (18) as promising compounds. The results suggest the relevance of exploring synthetic cyclitolic structures as potential antifungal leaders.

Keywords: Inositols, Conduritols, Chemoenzymatic, Antifungal activity, Bioautography, Amino acid conjugates.

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Article Details

Year: 2014
Page: [67 - 75]
Pages: 9
DOI: 10.2174/15701808113109990036