Antifungal Activity of a Library of Cyclitols and Related Compounds
Victoria de la Sovera,
Helio A. Stefani,
The antifungal activity of a library of 32 cyclitols and derivatives, including 6 previously unreported cyclitol
amino acid conjugates, was studied against the clinically important yeasts Candida albicans, Candida tropicalis and
Cryptococcus neoformans along with Saccharomyces cerevisiae. Bioautography followed by standardized microbroth dilution
methods were used and allowed to identify an azidoinositol glycoside (11) and an azidoconduritol linked to an aromatic
aldehyde (18) as promising compounds. The results suggest the relevance of exploring synthetic cyclitolic structures
as potential antifungal leaders.
Keywords: Inositols, Conduritols, Chemoenzymatic, Antifungal activity, Bioautography, Amino acid conjugates.
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