Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

Author(s): Zinatossadat Hossaini, Samereh Seyfi, Faramarz Rostami-Charati, Mehdi Ghambarian.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 10 , 2013

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A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of imidazoles.

Keywords: Indenoimidazole, Ninhydrine, Primary amines, three-component reaction, trichloroacetonitrile.

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Article Details

Year: 2013
Page: [788 - 790]
Pages: 3
DOI: 10.2174/13862073113169990046
Price: $58

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