A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for
the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with
trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures
for the high-yielding preparation of imidazoles.
Keywords: Indenoimidazole, Ninhydrine, Primary amines, three-component reaction, trichloroacetonitrile.
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