Development and Evaluation of Transdermal Organogels Containing Nicorandil
Dinesh K. Chellappan,
The objective of the study was to formulate a transdermal product containing Nicorandil as a model drug, because
it has been first drug of choice to treat angina and hypertension. A further objective was to reduce its side effects.
The transdermal product was prepared using various synthetic and natural gelling agents such as Carbopol 934p, Carbopol
974p, HPMC K15M and HPMC K100M. Various penetration enhancers were incorporated to enhance the diffusion
across the rat skin. A further objective was to formulate organogels and minimize the concentration of penetration enhancer
to 50% of the concentration used in gels and yet to achieve the maximum drug release. The prepared formulations
were evaluated for their physical appearance, viscosity, spreadability, drug content and freeze thaw cycle. Based on in vitro
studies across rat skin and human cadaver skin it was concluded that Nicrorandil transdermal organogel formulation
using HPMC K100M with 2% w/w Transcutol-P shows increase in cumulative diffusion of Nicorandil amongst all other
Keywords: Transdermal, nicorandil, carbopol, organogel.
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